Physiology 3120 Lecture Notes - Lecture 6: Juxtaglomerular Apparatus, Prostaglandin, Sodium Chloride

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Na levels too high in ecf = water moves into ecf via osmosis ecf volume increases. Amount of sodium in filtrate is detected and hormones are modified. Raas pathway works when na levels are low. Renin is enzyme made by juxtaglomerular cells in kidney that cleaves angiotensinogen into. Renin is only secreted by kidneys into blood in response to low na levels sensed by either chemoreceptors that detect chemical composition or by baroreceptors that detect bp. Ace is enzyme found in luminal membrane of endothelial cells within capillary beds that cleaves angi into angii hormone (only 8 peptides long) Ace in highest conc in lung capillary beds good idea since all blood eventually must go to lungs to get oxygenated. As angii flows through blood, not only does it have an effect on kidneys but also in adrenal cortex sitting on top of kidneys that gets stimulated to make aldosterone hormone.