Physiology 3120 Lecture Notes - Lecture 11: Tandem Pore Domain Potassium Channel, Antihistamine, Exocytosis

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Saliva secreted by three salivary exocrine glands to start process of digestion. Also need saliva to be able to taste food as liquefies out flavours and allows swallowing. Also needed to lubricate tongue to be able to talk. Submandibular gland secretes constantly to lubricate tongue, etc. Body of gland made up of ct and myoepithelial cells that contract to push acinar contents into duct towards mouth. Primary secretion (of saliva) coming from acinar cell initially isotonic. As primary secretion travels down into duct, ductal/epithelial cells modify it to make secondary secretion. Use transporters to reabsorb na/cl and secreting k/bicarbonate. When saliva flows slowly, cells have enough time for more modification hypotonic since ions reabsorbed but water stuck (impermeable cells) Secreted by cells in mouth not salivary glands: iga/lysozyme detects and breaks down viruses and bacteria/breaks down bacterial cell walls. Salivary secretion is only secretion in gi tract controlled by mostly neural regulation.