Physiology 3120 Lecture Notes - Lecture 1: Androstenedione, Cholesterol Side-Chain Cleavage Enzyme, Circulatory System
11 Aug 2016
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Document Summary
Leydig cells make testosterone and surrounded by bv to receive nutrients. Warm blood from core goes into testis they want to be cool! Counter current exchange system where incoming warm blood in arteries lose heat to outgoing cold blood in veins. Leydig cells make testosterone lh acts leydig cells. Sertoli cells make sperm fsh acts on sertoli cells. Lh binds to its receptor which is gpcr to stimulate camp production which activates pka. Pka triggers protein production including star and p450. Cholesterol brought in via bv as precursor to testosterone. Testosterone is an androgen so binds to androgen receptor (ar) Fsh binds to its receptor which is gpcr to stimulate camp production which activates pka. Cytoskeletal proteins maintain shape of sertoli cell. Abp maintains high local testosterone conc/increase half-life. Sertoli cells make fluid in which sperm flow thus added pressure helps to move fluid along. Bulbourethral gland (cowper"s gland) adds alkaline solution to counteract acidity of vagina.
