Physiology 3140A Lecture Notes - Lecture 3: Carcinogen, Oligosaccharide, Epidermolysis Bullosa

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Secreted by cells into the spaces that surround them. Bone and teeth: tensile strength tendons, transparent matrix for sight cornea, control cell behavior. Basal lamina at interface between epithelium and connective tissue. The terms basal lamina and basement membrane are used interchangeably. Essentially, the basal lamina is a series of proteins that keep the epithelial cells attached to the connective tissue. Note that fibroblasts are the ones producing the majority of the ecm: although not abundant throughout the connective tissue, they produce a lot of the ecm. Cells adhere to their extracellular matrix with adhesion molecules. These junction types are classified based on the connection to internal cytoskeleton: recall 3 types of cytoskeleton: actin (microfilaments), microtubules, intermediate filaments. Proteins that attach cell"s cytoskeleton to the ecm are called integrins: come in two classes, interact with ecm and cytoskeleton in the cell. If integrin associates with the actin cytoskeleton (microfilaments) focal adhesion: transient interactions.