Physiology 3140A Lecture Notes - Protein Kinase A, Adenylyl Cyclase, Phosphorylase Kinase

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Cyclic nucleotides: cyclic amp and protein kinase a. Synthesized from atp by plasma membrane-bound adenylate cyclase. Degraded to 5"-amp by cycle amp-specific phosphodiesterase. The primary physiological function of camp is to serve as an intracellular. Another physiological role for camp identified more recently is to act as a. 5" amp is biologically inactive second messenger to bind to and activate protein kinase a (pka). ligand for a specific class of odorant cation channel in olfactory neurons (intracellular in this case, so responds to signals/changes in environment inside the cell). Figure: not a homogenous process (localizes in one part of the cell). Adenylate cyclase removes two phosphates to create camp. Degradation to 5"-amp by cyclic amp-specific phosphodiesterase. Adenylate cyclase (first enzyme in cascade to convert atp into camp) Consists of two alternating hydrophobic and hydrophilic domains. Hydrophobic domains each contain 6 membrane-spanning domains. Multiple isoforms of adenylate cyclase stimulated by gs and inhibited by gi.

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