Physiology 4530A/B Lecture Notes - Lecture 7: Integrin, Collagen, Purinergic Receptor

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Mechanobiology: how mechanical environment affects biological activity of cells and how they respond. 2 ways that lead to mechanobiological response: external forces, (fluid) shear stress: in cartilage. These all lead to signal transduction which leads to protein synthesis, differentiation, etc. Cells respond differently depending on whether load is acute, chronic, and at what level it"s at (organ, tissue, cellular, molecular) Bone: bone is highly-oriented and can respond to mechanical environment by reorienting and resorption, bone responds to isf movement within and not the load itself directly. Cartilage: anisotropic: moves depending on direction of mechanical load. If it exceeds, leads to ecm damage which will degenerate tissue. 2 ways it works: cells are anchored to ecm by integrins, which link to cytoskeleton (actin via talin, vinculin, paxillin), which links to nucleus. So if matrix moves, cell moves as well: if matrix moves, channels on cell surface open/close and signals go into cell.

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