Physiology 4530A/B Lecture Notes - Lecture 4: Matricellular Protein, Sciatic Nerve, Rheumatoid Arthritis

38 views2 pages

Document Summary

Whole body ko: use sparc, ent1 to study disc, e. g. express cre under the control of a constitutive promoter like rosa26 (inert) with a goi that is only relevant to disc (sparc, ent1) Use mri to detect water (which should be in np b/c of aggrecans which imbibe water: if there are disc problems, there is less water signal. Pros: has complex microenvironment of ivd to study it. Cons: 4 legs so different (more) mechanical loading, size. Degenerated discs: indirectly causes pain because it places other spine parts under stress. Discogenic pain: pain originating from inside ivd. If you change main joint load, it changes facet joints which can lead to facet arthritis. Cause: break in vertebra so 1 slides forward: sports injuries cause this when there"s too much stress on lower back. Matrix of ivd causes degeneration in adjacent discs; also loss of h2o/pgs. Cause: tear leads to herniation (l4-l5, l5-s1: happens in physically active people.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents