Physiology 4530A/B Lecture Notes - Lecture 6: Hypercalcaemia, Osteomalacia, Cardiac Arrhythmia

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Bone as a tissue: when talking about cortical or cancellous bone: cortical = compact, cancellous = trabecular/spongy, composition. Ecm: collagen i (organic), hydroxyapatite crystals (inorganic; ca, po4), proteoglycans. Bone as an organ: the whole structure of a bone (multiple types of tissue that come together to perform a function: tissues in a bone: bone tissue, cartilage tissue, bone marrow, periosteum, fat, endosteum, vasculature, innervation, lymphatics. Periosteum: soft, connective, fibrous tissue lining inside surface of bone. Immature bone is called woven bone, which gets replaced/remodeled by lamellar. Haversian canals run longitudinally w blood vessels and nerves inside: concentric lamellae surround canals, canal + concentric lamellae = osteon. Circumferential lamellae run all the way around outside of bone. Outside of bone is formed by intramembranous ossification. Inside of bone is formed by endochondral ossification. In 1 sheet of bone, collagen fibres + hydroxyapatite crystals all going in 1 direction, and in adjacent sheet, opposite direction great resistance/strength.

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