Physiology 4600A/B Lecture Notes - Lecture 2: Gabab Receptor, Inhibitory Postsynaptic Potential, Ligand-Gated Ion Channel
16 May 2019
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Miniature epsp can be released spontaneously do not depend on action potentials. Evoked epsp, pre-synoptically you have huge amount of vesicles released: different situation thousands of vesicles. Main neuronal inhibition in cerebral cortex & brain: main inhibitory neurotransmitter in the brain, especially in the forebrain in the cortex. Gaba receptors can be type a or b: type a receptor antagonist: bicuculline & picotoxin, blockers of gaba-a receptors, we measure the action of gaba by looking post-synaptically looking at ipsps (inhibitory post-synaptic potentials) Inhibitory postsynaptic potential has early and late components microelectrode. Gaba terminal releasing gaba: post synaptically you have gaba-a and gaba-b receptors, different types of receptors on the membrane surface, note: can be pre-synaptic too. If you open a lot of chloride channels you get the equilibrium potential of chloride (-72mv) If resting is above -65, it takes you to -72 = hyperpolarizing: reverse potential of ipsp-a. Different experimental approaches are used to study epilepsy and seizures.
