Physiology 4640A/B Lecture Notes - Lecture 1: Wnt Signaling Pathway, Skeletal Muscle, Endoderm

• School: Western University
• Department: Physiology
• Course: Physiology 4640A/B
• Professor: Christopher Pin

Document Summary

Basic theoretical concepts of embryonic development: single cell human body, division, differentiation, generate pattern (key difference in development; critical) i. e. cell boundaries. Axis formation in development: examples of axis, describing an embryo pattern (map it in an axis) Mosaic development: the coming together of different pieces and patterns, there are patterning molecules in the early gametes of some organisms. Yellow plasm migrates to one side of cells & cells internalize it. Rna within myoplasm has tf for trigger of muscle formation. (cid:498)macho-1(cid:499) ~100 years later, the molecule responsible for yellow plasm is discovered. Mosaic intrinsic* determinants transcription factors* Regulative development: *black cells are what"s transplanted, mosaicism cannot explain everything! Initial movement from dorsal side of embryo (indicator of dorsal: moving dorsal cells to ventral does not rule out mosaic development. Key finding: convinced neighbouring cells to form dorsal axis. Changed fate: mouse is highly regulative. 3 embryos together = 1 fine mouse (chimeric) Regulative extrinsic* inductive events signaling molecules*