Psychology 2020A/B Lecture Notes - Lecture 18: Vasodilation, Angina Pectoris, Cyanide Poisoning
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Also k(cid:374)o(cid:449)(cid:374) as (cid:862)(cid:373)i(cid:374)o(cid:396) t(cid:396)a(cid:374)(cid:395)uilize(cid:396)s(cid:863) , (cid:271)ut distinguished from antipsychotics which are (cid:862)(cid:373)ajo(cid:396) t(cid:396)a(cid:374)(cid:395)uilize(cid:396)s(cid:863) Leo h. sternbach synthesized several compounds in cracaw, poland. In 1957 during a cleanup in the lab previously untested compound ro-5-0690 ability to calm animals. Developed to identify drugs that may possess desirable effects. If all drugs currently used to treat a condition produce a similar outcome on a test, test is considered useful screening test: elevated plus maze. Apparatus in the form of a + that is on legs and elevated. 2 of arms in maze are walled and 2 have no walls. Drugs which have axiolytic potential alter rats preference for walled arms, they spend more time in open arms: geller-seifer procedure. Takes place in a skinner box that has2 levers on the wall. 1 schedule vi with no shock and fr1 with shock (get food 2 ways, but latter is richer schedule) Undrugged animals choose vi when in effect and avoid fr.