Psychology 2220A/B Lecture Notes - Lecture 11: Evolutionary Developmental Biology, Lateral Sulcus, Neural Groove
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Stage 1: neurogenesis: cells of the neural tube divide to produce progeny cells, these progeny/protocells will become different types of cells. Stage 2: cell migration: glial cells extend from the central column of the tube (ventricular zone) to the outside. It then enters midbrain where it slows down and branches out, eventually establishing synaptic connection. Inside out development of cortex: they first form layer vi, then v, then iv, etc, starts with ventricular zone, intermediate zone, subplate, cortical plate, marginal plate, layers add between the cortical plate and the subplate. 3: or, it can become a glial blast and become an oligodendroglia or an astrocyte. Stage 5: cell death: we make way more neurons and synapses than we need, only the fittest neurons survive, also called neural darwinism . Necrosis: cell homicide, passive, unprogrammed cell death, cells swell, burst, disintegrate, causes inflammation that affects adjacent cells, can be due to trauma, disease, infection, poisons.