Rehabilitation Sciences 3060A/B Lecture Notes - Lecture 9: Basal Ganglia, Neurodegeneration, Idiopathy

• School: Western University
• Department: Rehabilitation Sciences
• Course: Rehabilitation Sciences 3060A/B
• Professor: Thomas Overend

Document Summary

Parkinson"s disease: what is it? progressive long term impact can die from it progress till you die neurodegenerative disorder. 78% of patients have idiopathic pd (idiopathic - no known cause) Parkinson"s disease: epidemiology a ects 2% of population > 65 years of age only 5-10% under 50 years of age: we"re not interested in this group. 1. 2-1. 5 x more males than females incidence increases dramatically with increasing age. 300/100,000 over 80 years old: what other condition does this remind you of, stroke, you should be able to relate these to the crude rates for stroke, sci, & tbi, parkinsons and stroke both increase with age. The basal ganglia: basal ganglia receives extensive input from cortex directs planned movement, basal ganglia is the problem with parkinsons, and almost all of its output is to the motor cortex via the thalamus. Relevant pathology substantia nigra axons go back to corpus striatum issue with nigrostriatal pathway is why parkinsons exists.