BI110 Lecture Notes - Lecture 27: Acetyl-Coa, Electronegativity, Cellular Respiration
Module 26: cellular respiration citric acid c(cid:455)cle and o(cid:454)idative. Pyruvate + coa + nad+ acetyl-coa + nadh + co2. Pyruvate must be transported across 2 membranes: non-selective porin allows diffusion across omm, mpc actively transports pyruvate across imm. Pyruvate oxidation is a 3 step process catalysed by a large complex called pyruvate dehydrogenase. Pyruvate decarboxylation: occurs within the mitochondrial matrix. Exergonic some energy released is captured by nadh, rest is lost as heat. Electrons removed in oxidations: accepted by nad+ or. Each acetyl group oxidized produces: 2 co2, 1 atp, 3 nadh, 1 fadh2, 1 gtp. 8 steps in the cycle, each with its own enzyme to catalyse the reaction. Pyruvate is converted to acetyl-coa before it enters the cycle. Acetyl groups are completely oxidized to co2. Electrons removed in oxidations: accepted by nad+ or fad. 7 out of 8 enzymes are soluble in the matrix. Electrons passed from nadh and fadh2 to o2.