BI110 Lecture Notes - Lecture 7: Lipid Bilayer, Dna Replication, Central Dogma Of Molecular Biology

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12 Dec 2017
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Killed virulent bacteria and live non- virulent bacteria. Dead mouse: non-virulent bacteria were transformed, therefor, some type of molecule in the debris carried the genetic information for virulence, did not identify molecule. Transformation: the conversion of cells from one state to another, as from non-virulent to virulent, when dna released to the environment by cell breakdown is taken up by recipient cells. What is replication: replication of dna, mutation; change in genetic information of dna, can lead to variation, variations; can alter fitness level, disproportionate amount in species, evolution; variation leads to evolution. Dna replication: two-stranded structure allows the copying (replication) of information and, daughter stands are produced, each a full copy of the original parental strand. Nucleotide structure: 3 components; phosphate group, sugar, and base, sugars are labelled with primes, bases do not have primes, phosphate group ionized because lost electrons. The 4 bases: purines, adenine and guanine, pyrimidines, thymine and cytosine.

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