BI110 Lecture Notes - Lecture 30: Adherens Junction, Cadherin, Cell Adhesion Molecule
Document Summary
What keeps cells organized into tissues: cell junctions = physically connect one cell to the next and anchor cells to the extracellular matrix. Cadherins: cadherins = transmembrane proteins that connect cell to other cells, they bind only to another cadherin of the same type, the extracellular domains of cadherins bind to one another, forming cell junctions. Integrins = transmembrane proteins that bind to extracellular matrix proteins. Integrins also act as receptors that communicate information about the extracellular matrix to the interior of the cell. Cell junctions: cadherins and integrins organize into cell junctions in the plasma membrane, allowing cells to adhere to one another, there are two types of cell junctions, adherens junctions, desmosomes. Adherens junctions: belt-like structure, composed of a band of microfilaments attached to the plasma membrane by cadherins, the cadherins attach to other cadherins in the adherens junctions of adjacent cells, thus connecting the microfilaments of cells.