BI110 Lecture Notes - Lecture 27: Protein Kinase A, Phosphorylase Kinase, Glycogen Phosphorylase
Document Summary
G protein activation: activated subunit binds to and activates the target protein, multiple cellular responses, ex. Increased heart rate, glycogen breakdown (glucose released from liver and muscle storage for a burst of energy), changes in gene expression (long-term) The image to the right shows a specific target protein phosphorylase kinase another target of pka, which has its own target called glycogen phosphorylase, which is what breaks down glycogen and releases it to the bloodstream. Protein kinase a has different targets according to what cell it"s in: note: phosphodiesterase deactivates adenylyl cyclase during response termination in adrenaline pathway. Signaling and gene expression: activated protein kinase a (pka), can also enter the nucleus to change gene expression. Receptor kinases: a receptor kinase, kit, is responsible for the production of pigment in skin, feathers, scales, and hair which can mutate. The phosphate groups provide binding sites for intracellular signaling proteins. Receptors that undergo conformational changes upon activation: g protein coupled receptor.
