BI110 Lecture Notes - Lecture 16: Sterol, Cholesterol, Active Transport

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29 Apr 2016
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Module 18: Membrane Transport
Passive Membrane Transport
-Hydrophobic nature of membranes restricts free movement of many molecules and substances
essential for life
Passive Transport: Movement of a substance across a membrane without need to expend chemical
energy such as ATP
Passive Transport and Diffusion
Passive transport can be driven by diffusion
Diffusion: Net movement of a substance from region of high concentration to lower concentration
Primary mechanism of solute movement within a cell and between cellular compartments
separated by a membrane
Rate of diffusion depends on the concentration difference on two sides of membrane, or
concentration gradient (A concentration gradient contains potential energy)
The rate of diffusion is faster in a higher concentration gradient rather than low
Diffusion rates: The higher the temperature, the greater the diffusion rate. At a given temperature,
smaller molecules diffuse faster
Two types of passive transport (Simple and facilitated)
Simple Diffusion: Passive transport of substances across lipid portion of membranes with their
concentration gradients
-Small uncharged molecules move rapidly. Large or charged molecules may be strongly impeded from
crossing membranes
Not every small or uncharged molecule is equal.
Even though ions are small, their charge does not allow them to pass the membrane
Friday October 23, 2015
Cholesterol and cortisol are derivatives of sterol which is a lipid found in the membrane which allows
them to enter the cell directly through the plasma membrane
Osmosis: Diffusion of water
-Two compartments separated by a semipermeable membrane.
Tonicity
Water moves into or out of cells depending on the tonicity of the solutions
Isotonic solution has the same solute concentration as the intracellular fluid (No net movement)
Hypotonic solution has a lower concentration of solute molecules compared to the intracellular
fluid (water moves into the cell)
Hypertonic solution has a higher concentration of solute molecules compared to the
intracellular fluid (water moves out of the cell)
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Document Summary

Hydrophobic nature of membranes restricts free movement of many molecules and substances essential for life. Passive transport: movement of a substance across a membrane without need to expend chemical energy such as atp. Diffusion: net movement of a substance from region of high concentration to lower concentration. Primary mechanism of solute movement within a cell and between cellular compartments separated by a membrane. Rate of diffusion depends on the concentration difference on two sides of membrane, or concentration gradient (a concentration gradient contains potential energy) The rate of diffusion is faster in a higher concentration gradient rather than low. Diffusion rates: the higher the temperature, the greater the diffusion rate. At a given temperature, smaller molecules diffuse faster. Two types of passive transport (simple and facilitated) Simple diffusion: passive transport of substances across lipid portion of membranes with their concentration gradients. Large or charged molecules may be strongly impeded from crossing membranes. Not every small or uncharged molecule is equal.

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