BI346 Lecture Notes - Lecture 11: Methyltransferase, Dna Replication, Methylation
Document Summary
Parental histone segregation out of all the histones that make up the nucleosome of a parental strand, half the histone go to the parental strand and the other half of the histone would have to be synthesized. The old histone = not modified and not acetylated. New histone = acetylated to tell cell which is new histone. In e. coli there is three ways: dna protein needs to have atp bound. Had (helper protein) stimulates the hydrolyzes of atp adp (wave of replication to reactive the origin: methylation. Methyl groups are in the way of methylase, so after dna replicated (temporary phase = hemi-methylated) blocks access to dnaa: interaction with dnaa with the data region. Just after replication (near origin, so replicated quickly) there are 2 data regions. After segregation there is only 1 copy per cell and there is enough dna to promte.
