BI459 Lecture Notes - Lecture 10: Centroacinar Cell, Pancreatic Duct, Parotid Gland

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Mixed exocrine and endocrine gland: exocrine part organized as a compound acinar gland similar to parotid gland, endocrine part in islets of langerhans. Bicarbonate to neutralize stomach acid prevent mucosal damage. Digestive enzymes to breakdown proteins, fates and carbohydrates for absorption via the intestinal mucosa into blood cck. Crucial hormones for normal glucose, lipid and protein metabolism. Secretes alkaline serous secretion: acinar cells, secrete proteases, lipases and amylases (digestive enzymes) stimulated by cck, gastrin, centroacinar cells (duct cells in middle of acini, secrete aqueous bicarbonate solution under stimulation by secretin. Secretion from the exocrine pancreas is regulated by both neural and endocrine control. Islets of langerhans = pale-staining cell clusters n humans ~1 million islets. Lecture 10: digestive hormones part ii regulation of endo and exo secretions: epsilon cells (<1%): secrete ghrelin. Glucose = preferred fuel for all body cells. Sources of glucose breakdown of: carbohydrates (glycogenolysis, non-carbohydrates (lipids, amino acids gluconeogenesis)

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