BI110 Lecture Notes - Lecture 10: Steroid Hormone Receptor, Signal Transduction, Cell Signaling
Document Summary
Gap junctions(animal cells) > spread of electrical signals b/w cells in cardiac muscle. Plasmodesmata (plant cells: speci c contact b/w cells. Cell adhesion molecules-integral membrane proteins that bind cells to one another or to extracellular matrix: intercellular chemical messengers. Stages of signal transduction: reception (ligand binds to receptor, transduction through signaling cascade (receptor activates signal transduction molecules, response of the cell (signal molecule initiates signal cascade) Reception by cell-surface receptor(intracellular: signal molecules, hormones, neurotransmitters, receptors, integral membrane glycoproteins, responses usually rapid, short-lived events, bind ligands with high speci city and low af nity. Surface receptors: binding of a signal molecule. Speci c t, like an enzyme binding substrate. Induces molecular changes in the receptor that activates it cytoplasmic end. Reception by receptor within cell (intercellular: signal molecules. Hormone binding domain & dna- binding domain: responses occur over a longer time.
