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Lecture 13

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Wilfrid Laurier University
Matthew Smith

 Clicker question answers:  Non-competitive inhibition of an enzyme-catalyzed reaction differs from competitive inhibition in that non-competitive inhibition:  Changes the conformation of the enzyme  Enzyme Regulation  Futile cycle occurs when 2 metabolic pathways run simultaneously in opposite directions and have no overall effect other than wasting energy  Enzyme activity is often regulated to meet the needs for reaction products  Allosteric regulation and feedback inhibition are important examples  Allosteric Regulation  Occurs w/ reversible binding of regulatory molecule to allosteric site; location on enzyme outside active site  High-affinity state (active form); enzyme binds substrate strongly  Catalyzes reactions quickly  Low-affinity state (inactive form); enzyme binds substrate weakly/not at all  Catalyzes reactions more slowly  Allosteric regulation is a mechanism of inhibition that can lead to activation/inhibition of an enzyme  See Fig 4.21; p 87  See also, regulation by "Covalent Modification" (p 88). E.g. phosphorylation  Feedback Inhibition  Product of enzyme-catalyzed pathway acts as regulator of reaction  Helps conserve cellular resources  Mechanism is allosteric regulation  See Fig 4.22 p 88  Isoleucine inhibits the first enzyme in this feedback inhibit
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