4 November, 2013
- Universal, ancient pathway.
- Doesn’t require O2
- In cytosol
- Glucose (6C) oxidized into 2 molecules of pyruvate (3C each)
- Electrons removed are delivered to NAD+ producing NADH
- Each glucose molecule oxidized produces
• 2 net ATP
• 2 Pyruvate
ATP produced during glycolysis is produced by kinase enzyme.
NAD+ is reduced by dehydrogenase enzyme
2 molecules of pyruvate still consume 75% of ATP
ATP synthesis by substrate level phosphorylation
- ATP molecule produced in glycolysis result from substrate level phosphorylation.
- Enzyme catalysed reaction
- transfers phosphate group
1, Which of the following processes occurs during glycolysis?
D. ATP production through substrate level phosphorylation.
Reactions of pyruvate Oxidation
- MPC- mitochondrial pyruvate carrier.
- ^ active transport
- pyruvate + CoA +NAD+ acetyl-CoA + NADH +H +CO 2
- pyruvate must be transported across 2 membranes
- non selective porins a