BI226 Lecture Notes - Lecture 10: Lethal Allele, Sickle-Cell Disease, Protein Structure
Document Summary
Chapter 12: the consequences of mutations: the canadian sphynx cat lacks hair due to a mutation in its genome. The sphynx breed originated in the us, but in toronto a selective breeding program produced kittens without hair in 1966. Process of finding gene(s) involved for certain phenotype or biochemical process. Random mutations introduced in genome and then look for strains with the phenotype of interest. Mutations are created in a single gene at a time, and then the activity of each gene is. Now possible since we have sequenced the genomes of many organisms but we don"t know what all of these genes do!!! Germline cells are defined as the gametes and their progenitor cells. Mutations found in the germline will be passed onto the next generation. Mutations here won"t be passed onto the next generation. Mutations here can cause cancer and have serious effects, but not for future.
