BI226 Lecture Notes - Lecture 2: Gc-Content, Ovarian Cancer, Phosphodiester Bond

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5 Feb 2018
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Watson, crick and wilkins received the nobel prize in 1962 for their elucidation of the structure of dna franklin died of ovarian cancer in 1958. Chargaff"s data on nucleotide base composition in the dna of various organisms. In all organisms, ratios of a to t and g to c are roughly 1:1. The basis of the watson-crick double helix model of dna: franklin and m. wilkins (1952) solved x-ray diffraction pattern of dna. Dna is helical structure with 20 diameter. Helix undergoes a complete turn every 34 . Phosphodiester bonds always form covalent link between 3" carbon of one nucleotide and 5" carbon of the next nucleotide and 5" carbon of the next nucleotide. A pairs with t and g pairs with c. Base pairs consist of hydrogen bonds (weak electrostatic bonds) between a purine and a pyrimidine (g with c, a with t)

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