BI417 Lecture Notes - Lecture 5: Dynamin-Like 120 Kda Protein, Hla-Drb4, Gene Duplication

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16 Nov 2016
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T cells: b cells make antibodies, t cells have diverse roles. Make cytokines to control immune response: both have receptors that specifically bind to an epitope. 2 kinds of t cells, killers and helpers (cd8+ is a killer) B cells express b cell receptor, t cells have t cell receptors allowing it to recognize the antigen (their epitope) Intact molecules: proteins, carbohydrates,lipids (even nucleic acids, present on the surface of a pathogen or soluble. Could be from inside the pathogen or on its surface. Presented by mhc (tcr binds to this too) Can recognize piece of peptide anywhere in protein. T cell receptors only recognize peptides expressed/presented by mhc. Two different polypeptide chains with one antigen- binding site. Looks like a(cid:374) a(cid:271)"s fa(cid:271) do(cid:373)ai(cid:374: one c domain, one v domain, gene rearrangement causes variability in v domain. But not like ab: after binding to antigen it does not undergo further mutations. B cell receptors remember infection over time (recognize epitope)

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