HE302 Lecture Notes - Lecture 9: Impaired Glucose Tolerance, Hyperinsulinemia, Insulin Resistance
Document Summary
Background: first described in 1988 by dr. gerald reaven, syndrome x: Impaired glucose tolerance: hyperinsulinemia, decreased high density lipoproteins. Increased tg: extensive re-working of definition over next 20 years. In 2009 joint position stand formalized a definition for what is now known as the. Metabolic syndrome: mets is a compilation of risk factors that predispose individuals to develop multiple comorbidities, prevalence is typically greater in men than women, latino (m: 34. 76; f: 28. 50%), african (18. 99; 24. 51%) Insulin resistance plays key role in developing risk factors. In canada, since 1980 adult ob 3x and childhood 7x. Making a diagnosis: according to the 2009 position stand a dx can be made when 3/5 of these risk factors are present. Back to insulin resistance: all the metabolic sequelae of mets brought on by insulin resistance, neuronal insulin signalling plays a part in appetite. Insulin resistance can be central and peripheral: therefore central insulin resistance promotes ei.
