HE435 Lecture Notes - Lecture 9: Etiology, Dyslipidemia, Vasodilation
Document Summary
Background: first described in 1988 by dr. gerald reaven, syndrome x, blank, blank, blank, blank, extensive re-working of definition over next 20 years. In 1009 joint position stand formalized a definition for what is now known as the. Metabolic syndrome: mets is a compilation of risk factors that, prevalence is typically greater in men than women, latino (m: 34. 76; f: 28. 50%), african (18. 99; 24. 51%, blank. In canada, since 1980 adult ob 3x and childhood 7x. Making a diagnosis: according to the 2009 position stand a dx can be made when 3/5 of these risk factors are present. Etiology: lifestyle factors, diet, blank, lack of physical activity, blank, largely influenced by environmental factors, blank, genes associated w. obesity, hypertension, lipid metabolism. Back to insulin resistance: all the metabolic sequelae of mets brought on by insulin resistance, blank, neuronal insulin signalling plays a part in appetite, blank. Insulin inhibits npy/agrp and stimulates pomc neurons in arc nucleus of the hypothalamus.
