HE435 Lecture Notes - Lecture 22: Abdominal Pain, Irritable Bowel Syndrome, Necrosis

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22 Mar 2021
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Hepatitis: liver inflammation, characterized by liver enlargement, jaundice, anorexia, discomfort, grey-white feces, dark urine, caused by a variety of factors, toxins, bacteria, viruses, hepatitis a, b, c, and parasites. Cirrhosis: causes/risks: hepatitis b, c and d, autoimmune hepatitis, primary biliary cirrhosis, fatty liver diseases, medicines like acetaminophen, antibiotics and anti- depressants, alcohol abuse over a long period of time, hereditary diseases, toxic metals, cystic fibrosis. Immune mediated intestinal pathology caused by gluten intolerance. Celiac: pathophysiology: villus atrophy in small intestine. Irritable bowel syndrome (ibs: very common, ~20% of the population, abdominal pain associated w/ disturbed defecation (relieved w/ defecation, loose stool, more frequently, pain at onset, feeling of incomplete evacuation, excess mucus, visible abdominal distention (bloating) Ibs: causes & risk factors: cause unknown, more common in women, usually presents in late teens-early 40s, hypersensitivities, stress, hormonal dysfunction (serotonin and gastrin, food poisoning/gi infections, microbiome.

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