HE435 Lecture 20: HE435 - Week 9 Lecture 20

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22 Mar 2021
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Neurological diseases parkinson"s disease and multiple sclerosis. Differential diagnosis of parkinsonism: parkinson disease (idiopathic or genetic, drug-induced parkinsonism (anti-dopaminergics, other: vascular parkinsonism, brain trauma, cns infection. Parkinson"s disease: usually idiopathic (cause for condition is unknown, substantia nigra degeneration causes dopamine deficiency in striatum, motor symptoms, dopaminergic therapy relieves motor symptoms. Etiology mostly unknown: primary known causes, genetic, drug induced (ie. calcium channel blockers, toxins (supported by the geographically varied incidence, head trauma, cerebral anoxia (severe hypoxia) Pathology: basal ganglia, group of nuclei in the brain situated at the base of the forebrain (striatum, globus pallidus, substantia nigra, nucleus accumbens, subthalamic nucleus, associated w. voluntary motor control, procedural learning ,eye movements, cognitive and emotional functions. Symptoms: often affects upper and/or lower limbs on one side of the body, generally spreads as disease progresses, at onset, tremors, rigidity, slow movement. Issues with fine motor skills: later symptoms, stooped posture, slow, shuffling gait, problems w/ balance.

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