HE440 Lecture Notes - Lecture 7: Extrachromosomal Dna, Glioblastoma Multiforme, Telomere
Document Summary
Tumour-promoting inflammation and microenvironment: develop supportive stromal microenvironment, tumour-promoting inflammation. Inflammatory cells can have tumour promoting activities: support neo-angiogenesis, tumour cell survival, and invasion, ex. Tumour suppressor nf2 gene product known as merlin: regulates cytoskeletal dynamics, strengthens cell-cell contacts, sequestering growth factors. Tumour-associated macrophages (tams: cross talk with tumour cells (stimulate back and forth, tams provide matrix-degrading enzymes that facilitate cell invasion, cancer is not all about oncogene/tumour suppressor genes. Inducing angiogenesis: generation of an efficient blood supply, new blood vessel formation neo-angiogenesis, angiogenic stimulator vegf-a, upregulated by oncogene activation, hypoxia, tumour associated inflammatory cells. Inhibitor is tsp-1: regulated by p53, tumour vasculature: abnormal, erratic blood flow, transient hypoxia, leakiness, sometimes haemorrhaging, not clear if tsp1 is oncogene or tumor suppresor, by its role alone we would think it would be suppressor. Genome instability and mutation: development of mutator phenotype, mutations in: Instability caused by: genes involved with maintenance of genomic integrity (brca1/2)
