PS268 Lecture Notes - Lecture 6: Coca Wine, Stimulant Psychosis, Cardiac Arrhythmia
Document Summary
February 26th, 2019: cocaine comes from the coca plant which is grown in south america (such as columbia, peru, and bolivia) Cocaine is first purified and extracted: 1859= purification, 1863= coca wine coca leaves. Alfred (albert) niemann isolates cocaine as the active ingredient in. Angelo mariani uses coca leaf extract in many products including lozenges, tea, and especially wine. Forms of cocaine: coca paste, cocaine hydrochloride (powder, freebase, crack (rock) Prepared by mixing cocaine with water and baking soda. Chronic effects of cocaine: formication hallucinations= obsessive scratching; thinking that there are bugs crawling on them and trying to remove them, continuously stuffy or running nose, bleeding of nasal membrane, intense cocaine craving. Amphetamine use today: about 10% of males have tried, about 5% of females have tried, cocaine and methamphetamine used instead; methamphetamine use is much less- about 2% Acute effects of ephedrine: amphetamines can cross the blood-blood-brain barrier; therefore there are central and peripheral effects.
