BCHM 2021 Lecture Notes - Lecture 9: Dermatan Sulfate, Keratan Sulfate, Heparan Sulfate

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Classical: e-cadherins (endothelial), n-cadherins (neural), p-cadherins (placental) Nonclassical: protocadherins, desmosomal, unconventional, cadherin junctions: homophilic (like-to-like) Ca2+ binding prevents flexing and creates a curved rod, shape: (>1mm) (<0. 05mm = no binding) Stretch of -catenin due to cell tension sensed by actin-myosin complex: allows vinculin to bind (which allows more actin filaments to interact, pulling: increases contractile force. Zonula adherens (adhesion belt): interacts with bundles of actin filaments. Intracellular cell-to-cell junction made of cadherins interacting with intermediate filaments. Desmosomal cadherins: desmoglein, desmocolin: which binds to: i. ii. Tight junctions: restricts membrane proteins & lipid movement, restricts extracellular molecule movement, formed by transmembrane proteins, claudin: resposnible for asssembly, occludin: responsibe for acting as a barrier. *claudin-claudin & occludin-occludin interaction c) tricellulin: helps seal the two membranes together. Connect adjacent cells (permeable to small soluble molecules) Formed by the proteins: connexins: for vertebrates b) Small inorganic ions and small water-soluble molecule (800-1000 daltons) purely passive move through.

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