BCHM 2021 Lecture 10: BCHM2021 Lecture 10 Ch 18 Cell death and chapter 20 Cancer
11 Aug 2016
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Document Summary
Apoptosis or cell death systematic programmed self digestion of the cell indicated by morphological changes such as shrinkage, cytoskeletal collapse, nuclear membrane disassembly, and nuclear chromatin condensing and breaking up into fragments. Apoptotic bodies form from the bulging outwards of apoptotic cells that leads to breaking apart into small membrane-bound fragments chemically distinct from other cells signaling macrophages to engulf and digest them. Cell necrosis swelling then bursting of a cell due to acute insult (eg. trauma, lack of blood supply) spilling its contents to neighbouring cells causing an inflammatory response. Caused by energy depletion leading to metabolic defects and the loss ion gradients. Necroptosis programmed cell death due to a regulatory signal from other cells. Quality control to deplete lymphocytes after infection and t & b lymphocytes that fail to produce antigen receptors or produce self reactive receptors and. Cell proliferation damaged tissues that have high cell proliferation for recovery are kept in check.
