BCHM 2021 Lecture Notes - Lecture 17: Telophase, Actomyosin Ring, Apoptosis
21 Oct 2012
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M-cdk activation causes all early events of mitosis. Assembly of mitosis spindle break down of nuclear envelope. It causes re-arrangements of the actin cytoskeleton + golgi chromosome condensation. Attached to the sister chromatids at the kinetochore: astral. Beginning of mitosis: become shorter and more dynamic. Dyneins: minus end directed pull tubules to cortex. Kinesin 4,10 to plus end carry chromosomes. Question: it is estimated that as many as 25% of kinetochore microtubules and 75% of interpolar microtubules are not anchored to the centrosomes. In spite of that, all microtubules are focused tightly at the spindle pole why don"t the microtubules that weren"t nucleated by centrosome splay out away from the poles. Answer: microtubules that are not directly connected tho the centrosomes are held in place by minus- end-directed motors, which link them to the other microtubules[internet] 2 kinetochores per pair of chromatids = 92 humans.
