BIOL 2021 Lecture Notes - Lecture 84: Pyruvate Dehydrogenase Complex, Dihydrolipoamide Dehydrogenase, Citric Acid Cycle

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9 Jul 2017
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Pyruvate dehydrogenase complex: the pyruvate dehydrogenase complex and the citric acid cycle enzymes exist in the matrix of the mitochondrion in eukaryotes, pyruvate in generated by glycolysis in the cytosol and needs to be moved into the mitochondria. Mitochondria have a two membrane system: outer membrane: permeable to small molecules, inner membrane: not permeable has specific integral membrane protein transporters, region between the two membranes = intermembrane space. Pyruvate generated in cytosol enters the mitochondrion (aerobic fate of pyruvate) Pyruvate translocase transports pyruvate into the mitochondria in symport with h+ Complex: pyruvate dehydrogenase complex (pdh complex) is a multienzyme complex containing: 3 enzymes + 5 coenzymes + other proteins (+ atp coenzyme as a regulator) Overall reaction of pyruvate dehydrogenase complex: multienzyme complex (36 subunits!, pyruvate + coash + nad+ acetyl-coa + co2 + nadh + h+ Roles of the coenzymes of the pdh complex.

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