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Lecture 7

Lecture 7 - Chapter 12 - January 29.docx

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BIOL 2021
Patricia Lakin- Thomas

January 29, 2013 Lecture 7 – Compartments and Protein Sorting  Mitochondria – other spaces o Inner membrane import  Requires two sequences  Protein + stop transfer sequence + signal mitochondria o Intermembrane Space  Same as inner membrane space + protein cleavage  Chloroplasts – Fig 12.21 o 3 compartments o 3 membranes o Specific Membrane for each  Thylakoid – figure 12.29 o Similar to mitochondria  Signal sequence  Protein translocators o Differs from mitos  Protein translocators are difference  Energy from GTP and ATP  NOT membrane potential  Second signal sequence  Chloroplast signal seq – thylakoid seq – thylakoid precursor Endoplasmic Reticulum  Inner lumen is continuous o Reticulum = network  Rough ER – ribosomes for protein synthesis  Smooth ER – lipid synthesis  Function of ER o Synthesis of proteins  Transmembrane, secreted, lumen of ER, Golgi, lysosomes, made in Rough ER o Most lipid synthesis for organelles – smooth ER o Ca2+ store signalling – like muscle contraction  Sarcoplasmic reticulum o Co translational import of proteins  Post translational  Nuclei, mitochondria, chloroplasts  ER: co-trans  Ribosomes start translating in cytosol  Signal sequence made first – start transfer sequence  Signal Recognition Particle (SRP) – binds to sequence  Pauses translation  Binds to its own receptor (within the ER membrane)  Protein translocator binds  SRP and SRP receptor leave  Translation restarts Free vs. Bound Ribosomes  Polyribosome – many ribos on one mRNA  Same pool of ribosomes for cytosolic and ER proteins  Soluble proteins in ER
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