BIOL 2021 Lecture : Ch. 17 - Cell Cycle Part 2 A summary of the chapter and lecture notes on the cell cycle, part 2. Includes illustrations and graphics from the textbook.
Document Summary
M-cdk activation causes all early events in mitosis. Activation of m-cdk: increase m cyclin gene expression. Cdk activating kinase (cak) puts on an activating phosphate. All that needs to be done is remove inactivating phosphate to become active: activation of cdc 25 phosphatase. Cdc 25 activation : don"t know what activates it. Phosphorylates proteins that cause the breakdown of nuclear envelop (lamins) Proteins called condensing condenses chromosomes and winds up dna (above). 3 kinds of microtubules with different roles: interpolar: between the poles. Attached to sister chromatids at kinetochore: astral. At beginning of m phase (mitosis), mcdk is activated which causes formation of spindle. Mcdk phosphorylates map, microtubules become shorter and more dynamic. Gets put/created in centrosome causing more microtubules to form. Pushes poles apart (2 feet attach to different microtubules) Attached to chromosomes and carry them to plus end of microtubules which is where they need to be at metaphase.
