BIOL 2021 Lecture Notes - Lecture 13: Phosphatidylinositol (3,4,5)-Trisphosphate, Protein Kinase B, Protein Kinase
• Insulin like growth factor = IGF
• Fig 15-53 PI 3-kinase and cell survival
o IGF stimulates cell survuival and growth.
o IGF > RTK > PI 3-kinase > PI(3,4,5)P3.
o Akt = protein kinase B = PKB.
o Phosphoinositides-dependent protein kinase 1 = PDK1.
o Akt activated > targets phosphorylated > cell growth and survival.
o No need to worry about the later stage of the pathway, only looking at the
early stages.
o An extracellular survival signal activates an RTK, which recruits and
activates PI 3-kinase. The PI 3-kinase produces PI(3,4,5)P3, which serves
as a docking site for Akt and the phosphoinositide-dependent kinase
PDK1, and brings them into proximity at the plasma membrane. The Akt is
phosphorylated by PDK1, which activates the Akt. The activated Akt now
dissociates from the plasma membrane and phosphorylates various target
proteins.
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