BIOL 2021 Lecture Notes - Lecture 24: Bacitracin, Lactam
Document Summary
Other protein secreton systems are vital for pathogens. Multple chain lin& fence structures iith crosslin&s eetieen them give the cell iall strength. Many of the components of the eacterial peptdoglycan are synthesized iithin the cell eut are assembled outside of the cell. Bacitracin interferes in eetieen steps 4-5 (refer to peptdoglycan synthesis diagram) Can ee used as an anteiotci eut it"s a ead one eecause its toxic and poor oral eioavailaeility) so it could ee used only topically. Rememeer lysozyme and ihat it cleaves in peptdoglycan. Penicillin is a -lactam anteiotc that prevents cross-lin&ing ma&ing the nei cell iall iea&er. It iill only ior& in a cell iall that is eeing neily synthesized.
