BIOL 2070 Lecture Notes - Lecture 1: Epothilone, Paclitaxel, Neutropenia
Document Summary
Epothilones, a recent class of microtubule stabilizing drugs for future chemotherapeutic treatments. Taxol is a commonly known drug used for chemotherapy to treat different kinds of cancer. It is an effective agent that targets solid tumors in a person who"s affected by cancer. The way taxol works is that it hyperstabilizes polymerized microtubules in the cell, which causes mitotic activity interruption and toxicity in multiplying cells (bollag et al. Numerous experiments had been conducted to improve taxol through modifying its structure and combining it with other therapies. However, the drug"s researchers aiming to further taxol"s efficiency. Also due to its low solubility, it had to be mixed with cremophor, which is risky because cremophor could affect cardiac functions and could cause an individual to develop severe hypersensitivity (bollag et al. Because of taxol"s complexity and drug that could mimic taxol"s cancer treating properties. beneficial limitations, the researchers in this study had hoped to find a better alternative.
