BIOL 2905 Lecture Notes - Lecture 9: Septic Shock, Listeria, Intracellular Parasite
26 Nov 2016
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Listeria intracellular pathogen: mode of entry norton animation; http://www. wwnorton. com/college/biology/microbiology2/animations. aspx. Listeria species include enteric pathogens such as listeria monocytogenes, that may contaminate foods such as cheese and sauerkraut. When listeria enters the digestive tract, the immune system mounts an attack. Macrophages engulf the bacteria by phagocytosis: the internalized vesicle is called a phagosome. Normally, a phagocytosed bacterium would be digested by the macrophage, but. Listeria releases a toxin that lyses the phagosomal membrane, allowing the bacterium to move freely through the cytoplasm. Inside the cell, bacteria have a rich medium for growth and reproduce quickly: because they are hidden inside cell, they can evade the antibodies of the immune system. Protein that can open up cytokine inducing genes in immune cells: e. g. interleukin (il, therefore, induces septic shock. Elaborate processes have evolved for transcription and duplication of this genetic material. Dna proteins, histones: other proteins found on dna: transcription factors.
