BIOL 3051 Lecture Notes - Lecture 14: Liniment, Rheumatoid Arthritis, Diclofenac
20 Apr 2020
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Document Summary
Primary oa is idiopathic & seen in elderly. Secondary oa is due to trauma to joint, rheumatoid arthritis, gout, congenital abnormalities, hematologic genetic disorders (leukemia) Defined as biochemical & inflammatory changes w/ cartilage matrix, joint cavity & support structures. Improve muscle strength to protect cartilage, ligaments & joint capsule. Prevent & reduce damage to joint cartilage, bone, ligaments, muscle & local nerves. Blood work inflammatory markers (cbc, rheumatoid factor, est, crp) Joint fluid analysis is valuable to exclude infection. Exercise & aerobic activities reduce pain & improve function, reduce need for hip replacement. Surgery is option for serve oa of knee & hop. Topical analgesics: reduce risk of side effects, topical nsaids useful in elderly- increase risk of gi, renal, cv & other oral nsaid side effects, topical diclofenac- voltaren, pennsaid, rub a-535. Simple analgesics: first choice- acetaminophen b/c low risk of side effects but provide minimal relieve, max dose is 4g.
