BIOL 3051 Lecture Notes - Lecture 20: Bisphosphonate, Bone Remodeling, Raloxifene
20 Apr 2020
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Document Summary
Sarcopenia & decrease muscle mass & function are prevalent in older adults & increase falls. Vitd 800-1000 units is associate w/increasing muscle strength and balance & decrease falls. Older adults should practice bone-healthy lifestyle, ingest adequate calcium & vitd, walking & lifting light weights can stimulate bone remodeling. Oral bisphosphonate admin is difficult for bed bound, difficulty swallowing, have fluid retentions, difficult to stay upright. Bone turnover markers or bone biopsy need to differentiate bone disease. Vitd deficiency common in patients w/ ckd should monitor 25(oh) vitamin d concentrations. In patients with crcl< 30ml/min, bisphospnoates aren"t recommended due to accumulation. Zolendronic acid is associated w/tubular necrosis-like reduction in gfr. Cancer, metastases & chemotherapies can cause bone loss & osteoporosis. Certain osteoporosis meds use to prevent bone loss during chemo or cancer. Bisphosphonates & denosumab decrease chemotherapy-induced bone loss & fractures. Raloxifene decreases risk of invasive breast cancer in high-risk women.
