BIOL 3051 Lecture Notes - Lecture 17: Diclofenac, Nonsteroidal Anti-Inflammatory Drug, Ketoprofen
20 Apr 2020
School
Department
Course
Professor
Document Summary
Is the patient taking any of these drugs and if so, is the timeframe consistent?) Nsaids: chronic use (low-dose aspirin) can cause upper gi injury, pud, superficial erosion. Use of nsaids is age related, as age-related changes occur with gastric mucosal defense. Factors that effect nsaid effect are: potency, longer duration of effect, inhibition of cyclooxygenase-1 (cox: vs cox2 isoenzymes are associated with increased risk. Non-specific nsaids block the activity of cox1, a constitutive enzyme, that produces protective prostaglandins. Prostaglandins that protect gi and have important platelet activity. So blockade of these cox1 enzymes results in gi side effects like abdominal pain, nausea, diarrhea, ulcer. Non-selective nsaids : asa, ibuprofen, ketoprofen, naproxen, diclofenac. Nsaid ulcer are increased with use of multiple nsaids or concomitant use of low-dose asa, oral bisphosphonates, corticosteroids, anticoagulants, antiplatelets drugs, serotonin reuptake inhibitors (sri) Ulcer complications are increased when nsaid + low-dose asa. Corticosteroids + nsaids increases risk of ulcer.
