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BIOL 3120 (14)
Lecture 2

Lecture 2 Learning Objectives.docx
Lecture 2 Learning Objectives.docx

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School
York University
Department
Biology
Course
BIOL 3120
Professor
Tanya Da Sylva
Semester
Fall

Description
Lecture2LearningObjectivesContrastthetypeofantigensrecognizedandtheeffectorfunctionsofCD4andCD8TcellsDiscusstheroleofreceptormediatedendocytosisinBcellactivationDescribethemechanismsbywhichantibodiescombatinfectionDefinespecificinthecontextofanindividualantibodymoleculeDefineantibodyrepertoireThetotalvarietyofantibodiesthatapersoncanmakeSketchasurfaceimmunoglobulinandanantibodyLabelthetwochainstheantigenbindingsitesthevariableandconstantregionsthehingeregionsandthegenerallocationofdisulfidebondsIndicateanydifferencesbetweensurfaceIgandantibodystructureSketchtheFabandFcfragmentsandindicatewhichregionsofantibodyarerepresentedbyeachSketchtheFabandFcfragmentsandindicatewhichregionsofantibodyarerepresentedbyeachDiscusstheroleofFabandFcfragmentsinstudiesofantibodystructureandfunctionDescribethefunctionofthehingeregionofIgantibodyListthefivemainisotypesofimmunoglobulinsandtheircorrespondingheavychaingenesListthetwoisotypesoflightchainandtheircorrespondinglightchaingenesDefineanddistinguishbetweenvariabledomainconstantdomainandimmunoglobulinlikedomainsDefinehypervariableregionsandframeworkregionsofVdomainsanddescribetheirgeneralformationandlocationintheVdomainDefinecomplementaritydeterminingregionDefineantigenicdeterminantepitopeanddescribewhatisknownasamultivalentantigenDistinguishbetweenlinearandconformationaldiscontinuousepitopesDiscussthebindingofantigenstoantibodiesfocusingontheforcesinvolvedandtheaffinityBrieflydiscussthecreationofmonoclonalantibodiesandanexampleoftheiruseDistinguishbetweenpolyclonalandmonoclonalantibodiesDiscusstheneedforchimericmonoclonalantibodiesandhumanizedantibodiesListthedifferentsegmentsthatencodeanimmunoglobulinVregionandCregionDistinguishbetweenthesegmentsencodingheavyandlightchainsDescribehowsegmentsthatencodeanIgVregionheavyandlightformthehypervariableregionsSketchthearrangementofgenesegmentsintheheavyandlightchainbothingermlineDNAandaftersomaticrecombinationlevelofdetailsimilartoFigure417GivethelocationwheresomaticrecombinationoftheIglocioccursDefinegermlineconfigurationandsomaticrecombinationVDJrecombinationDiscusshowsomaticrecombinationcontributestoclonalselectionDescribetheRSSandtheimportanceofthe1223ruleDescribetheprocessofsomaticrecombinationanddiscusstheroleofrecombinationsignalsequencesRSSandtheVDJrecombinaseinsomaticrecombinationDescribethecomponentsoftheVDJrecombinaseDescribetheroleofnonhomologousendjoininginsomaticrecombinationDistinguishbetweenthecodingjointandasignaljointDescribethegenerationofjunctionaldiversityduringgenerearrangementusethetermsheptamerRAGcomplexhairpinPalindromicPnucleotidesterminaldeoxynucleotidyltransferaseTdTNnucleotidesexonucleasesligationandcodingjointDiscusstheimportanceofjunctionaldiversityDescribetheroleofalternativemRNAsplicingincreatingIgMandIgDDefineanddescribethefunctionofallelicexclusionDescribetheroleofIgaandIgbintheBcellreceptorDefinesomatichypermutationanddiscusstheprocessofsomatichypermutationfocusingontheroleofAIDandthephenomenonofaffinitymaturationDefineisotypeclassswitchinganddiscusstheprocessofisotypeswitchingfocusingontheroleofAIDandswitchregionsDistinguishbetweeneffectorfunctionandantigenspecificitydescribehoweachisaffectedbyisotypeswitchingListthefunctionsandpropertiesthatcanvarybetweenIgisotypesDiscussthebasiccharacteristicsofIgGIgAandIgELecture3LearningObjectives
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