BIOL 4380 Lecture Notes - Lecture 11: Olfactory Receptor, Olfactory Bulb, Vomeronasal Organ
13 May 2018
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• Odorant receptor proteins: all of them have very stereotypic topology. They have 3
functional parts to them: the transmembrane domain, the extracellular domain is responsible
for the binding of the molecule, the intracellular domain which is responsible for the G protein
atiatio. Thee’s uite a it of oseatio aog the odoat eepto failies. The ue
of genes in humans are 950, largest single gene family. 60$ are pseudogenes, 40% are still real
genes. All of these genes are capable of recognizing a variety of odorants, there are just
different affinities. This is why we can smell a lot more odorants compared to the number of
genes.
• Thee’s ol oe odoat eepto that’s epessed pe ORN.
• 2 ORNS expressing 2 specific members of the, I7 among all ORNS is distributed in a
particular pattern and occupies only a particular section. The M71 has a completely different
domain. (Listen to recording for this?)
• Mooalleli epessio: e’e diploid, e hae alleles fo eah gee, eah of these
ORs is expressed from one allele but not the other.
May 10th
• No hapte 7 i the fial, e’e goig to fiish hapte 5.
• The vomeronasal system:
o It is a system that allows animals to respond to various stimuli relating to predation or
responding to various sexual cues in mates.
o This system is absent in most primates, including humans: we have to look at this
system in mice instead. The primary location of the peripheral vomeronasal organ (VO):
o There are 2 types of receptors in the VO, the difference between is that they express 2
types of receptors: V1R and V2R. Both of these just like odorant receptors are 7 helix membrane
receptors (GPCRs). V2R has a much larger cytoplasmic domain. The functional difference: V1Rs
respond to pheromones (chemical cues in sexual behaviours) and V2Rs respond to kairomones
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Document Summary
Odorant receptor proteins: all of them have very stereotypic topology. They have 3 functional parts to them: the transmembrane domain, the extracellular domain is responsible for the binding of the molecule, the intracellular domain which is responsible for the g protein a(cid:272)ti(cid:448)atio(cid:374). The(cid:396)e"s (cid:395)uite a (cid:271)it of (cid:272)o(cid:374)se(cid:396)(cid:448)atio(cid:374) a(cid:373)o(cid:374)g the odo(cid:396)a(cid:374)t (cid:396)e(cid:272)epto(cid:396) fa(cid:373)ilies. The (cid:374)u(cid:373)(cid:271)e(cid:396) of genes in humans are 950, largest single gene family. 60$ are pseudogenes, 40% are still real genes. All of these genes are capable of recognizing a variety of odorants, there are just different affinities. This is why we can smell a lot more odorants compared to the number of genes. The(cid:396)e"s o(cid:374)l(cid:455) o(cid:374)e odo(cid:396)a(cid:374)t (cid:396)e(cid:272)epto(cid:396) that"s e(cid:454)p(cid:396)essed pe(cid:396) orn. 2 orns expressing 2 specific members of the, i7 among all orns is distributed in a particular pattern and occupies only a particular section. The m71 has a completely different domain. (listen to recording for this?)
