BIOL 4510 Lecture : lecture17-receptors2-revised.pdf
Document Summary
This section reviews the autonomic nervous system and summarizes the major targets of adrenergic and muscarinic (m2) activaton. Much of the material to follow has already been covered. Funny current: hyperpolarization-activated cation (hcn) channels or if. Ca2+ thereby increasing spontaneous ca2+ release and incx: accelerates conduction through the av node (see below) Increases serca2a activity by reducing pln and sln affinity for pump: pln and sln monomers are natural inhibitors of serca2a. Increases pln pentamer formation which decreases monomers (mass action) Allows serca2a to better compete with ncx for ca2+ entering cytosol from. L-type ca2+ channels or ryr2 opening thereby placing more ca2+ into sr. Once ca2+ transients rise the ncx is able to compete with serca2a for the. Ca2+ (serca2a is a high affinity low capacity transporter while ncx is a low affinity high capacity ca2+ transporter). Elevated sr ca2+ increased po for ryr2 and spontaneous ca2+ release.
