BIOL 4510 Lecture Notes - Lecture 11: Treadmilling, Cytokinesis, Immunoglobulin Superfamily
Document Summary
There are two properties of muscle you need to fully understand: the force-length relationship, the dependence of force generation on the intracellular ca2+ levels. Ca2+ acts as a catalyst for activating the atpase in muscle for the purposes of conversion of chemical energy into force. 1. 01. 41. 82. 22. 63. 03. 43. 8020406080100myofilament overlap cardiac muscle(starling)sarcomere length ( m)tension (% max)heavy filament myosin. Myosin is the molecular motor of the contractile protein machinery. It is the protein that converts chemical energy from atp to mechanical energy, thus generating force and movement. There 17 different classes of myosin; myosins are involved in force generation and movement in muscle (cardiac, skeletal and smooth muscle are comprised of type ii myosins. Type ii dimerizes two myosin molecule are connected by coil-coil structures in the tail. Type i is the most primitive myosin: moves molecular cargos like vesicles within cells; they are ca2+-dependent (i. e. activated by a rise in intracellular ca2+) via calcium/calmodulin binding in neck region.
