CHEM 3050 Lecture Notes - Lecture 5: Glycogen Synthase, Glycogenin, Gluconeogenesis
2 May 2018
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CHEM 3050
Lecture 5
Step 1 of glycolysis is bypassed also mediated by Glucose-6-
phosphatase
Active site histidines, similar to previous enzymes. The lone pairs
on his are going on to phosphate to catalyze the breakage of the
bonds
ΔG’° = -13.8 kJ/mol
Overall gluconeogenesis, the process of gluconeogenesis is :
2 pyruvate + 4 ATP + 2 GTP + 2 NADPH + 2H+ + 4H2O
Glucose + 4ADP +2GDP + 6 Pi + 2NAD+
ΔG’° = -16 kJ/mol due to the break points in the glycolysis step
that the overall reaction is exergonic
Happens mostly in the liver when there’s lots of ATP around
stores excess sugar as glycogen (but it can happen in muscles
and store glycogen there too)
three enzymes that are used in the storage of glucose as
glycogen (poly alpha 1,4 glucose)
Glycogen synthase takes UDP activated glucose and adds it to
another glucose from the non reducing end in a 1,4 linkage.
It needs poly alpha 1,4 linkages to function with a glycogenin core
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Step 1 of glycolysis is bypassed also mediated by glucose-6- phosphatase. The lone pairs on his are going on to phosphate to catalyze the breakage of the bonds. Overall gluconeogenesis, the process of gluconeogenesis is : Glucose + 4adp +2gdp + 6 pi + 2nad+ G" = -16 kj/mol due to the break points in the glycolysis step that the overall reaction is exergonic. Glycogen synthase takes udp activated glucose and adds it to another glucose from the non reducing end in a 1,4 linkage. It needs poly alpha 1,4 linkages to function with a glycogenin core. Glycogenin is the primer generator, making the linkages and keeping them held; making a glycogenin core and the strings of glucose branching out. Lets the synthase do its thing (this is all: ch. The glycogen branching enzyme (gbe1) transfers long chaing of alpha 1,4 linked glucose to an alpha 1,6 branch point.
